By Mary J. Laughlin, Hillard M. Lazarus
The world over well-known physicians and researchers evaluation either the fundamentals of allogeneic stem mobile transplantation and up to date advances within the box, rather as they relate to antitumor results and graft-versus-host ailment additionally they supply specific decision-tree analyses to lead clinicians in picking out and handling their allogeneic transplant sufferers. The strategies mentioned conceal numerous components, starting from stem phone mobilization in common donors, to symptoms for allogeneic transplantation except hematologic malignancies, to using nonmyeloablative conditioning regimens. The authors additionally discover new advancements within the optimum choice of unrelated allogeneic grafts (e.g., matched unrelated donor, in part mismatched friend, or umbilical twine blood), the use allogeneic peripheral blood stem mobile vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
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Additional resources for Allogeneic Stem Cell Transplantation (1st Edition)
Predicting Outcome: Role of Monitoring MRD in Ph+ ALL Following Transplantation Several studies of MRD status following allogeneic transplantation provide intriguing information about the risk of relapse in Ph+ ALL and may help to identify patients who are likely to relapse (45–49). All of these studies found that patients who are consistently BCR/ ABL– following transplantation are unlikely to relapse and may become long-term survivors. Conversely, patients who are BCR/ABL+ following transplantation seem to be at high risk for subsequent relapse.
Cassileth PA, Harrington DP, Appelbaum FR, et al. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. N Engl J Med 1998;339:1649–1656. 22. Bensinger W, Martin P, Storer B, et al. Transplantation of bone marrow as compared with peripheral blood cells from HLA-identical relatives in patients with hematologic malignancies. N Engl J Med 2001;344:175–181. 23. Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study.
Cord blood stem cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd ed. Blackwell Science, London, 1999, pp. 431–443. 53. Hansen JA, Petersdorf, EW. Unrelated donor hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd ed. Blackwell Science, London, 1999, pp. 915–928. 54. Anderson JE, Appelbaum FR, Schoch G, et al. Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors.
Allogeneic Stem Cell Transplantation (1st Edition) by Mary J. Laughlin, Hillard M. Lazarus