By Maren Oehlmann, Cathal Mahon, Heinz-Peter Nasheuer (auth.), Director Fabrizio d'Adda di Fagagna, Director Susanna Chiocca, Director Fraser McBlane, Director Ugo Cavallaro (eds.)
Proceedings of the second Annual IFOM-IEO assembly on melanoma. it is a new assembly, it has approximately 2 hundred attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, eire, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA.
The second IFOM-IEO overseas assembly on melanoma will supply a discussion board during which the world’s prime melanoma researchers and younger scientists will talk about the newest advances in molecular oncology. The effect of modern breakthroughs in uncomplicated study and of rising applied sciences on molecular medication in melanoma might be highlighted.
Read or Download Advances in Molecular Oncology: Edited under the auspices of the European Institute of Oncology (IEO) and The FIRC Institute of Molecular Oncology Foundation (IFOM) PDF
Similar european books
Given the present unrest within the heart East, this e-book evaluates the power of the ecu Union via expansion to avoid a possible clash constructing among key actors within the near-eastern Mediterranean sector; specifically Greece, Turkey and Cyprus. Cyprus and the Cyprus factor becomes more and more very important within the following couple of years given the finishing touch of accession negotiations, and the signing of the Accession Treaty in April 2003 among Cyprus and the eu Union.
Exogenous and Endogenous affects on Metabolic and Neural keep an eye on, quantity 1: Invited Lectures covers the complaints of the 3rd Congress of the ecu Society for Comparative body structure and Biochemistry. The ebook offers 35 papers that hide numerous facets within the keep an eye on of physiological actions in animals.
Whilst i used to be requested to prepare this symposium on marine producti vity, it made me give some thought to what facets of this topic will be stimulating to a heterogeneous crew of laboratory-oriented physiolo gists and biochemists. lately there were numerous books which discusses the technique wide-spread in basic construction experiences and defined the value of photosynthetic CO aid 2 in a variety of parts of the world's oceans.
- Changing Work and Community Identities in European Regions: Perspectives on the Past and Present
- Foreign Capital as an Instrument of National Economic Policy: A Study based on the Experience of East European Countries between the World Wars
- Consolidation in the European Financial Industry (Palgrave MacMillan Studies in Banking and Financial Institutions)
- ECOOP’ 93 — Object-Oriented Programming: 7th European Conference Kaiserslautern, Germany, July 26–30, 1993 Proceedings
Extra resources for Advances in Molecular Oncology: Edited under the auspices of the European Institute of Oncology (IEO) and The FIRC Institute of Molecular Oncology Foundation (IFOM)
As a control, we used an LATS2 knockdown construct (Figure 5F). These results show that a combined effect of RNA destruction and translation inhibition is used by miR-372&3 to silence LATS2. miR-372/3 was predicted to bind two sites in the 3′-UTR of LATS2 that are highly conserved between human, mouse, and zebrafish (Figure 5D). To further substantiate LATS2 as a direct target of miR372&3, we cloned its 3′-UTR downstream of the firefly luciferase gene (pGL3-LATS2) (Figure 5E). We transfected either pGL3-LATS2 or the controls pGL3-372 and pGL3-373 (containing a miR-complementary sequence in their 3′-UTR) or pGL3 into Tera1 and MCF-7 cells (respectively positive and negative for miR-371–3) (Figures 4D and S6).
As demonstrated by RPA, miR-Vec-372mut and miR-Vec-373mut indeed failed to express miR-372 and miR-373, respectively (Figure 3A). Note that miR-Vec-372mut still expressed miR-371 to a similar extent as the original miR-Vec-371&2. We then tested these constructs in a YFP-competition assay to detect possible growth advantages conferred by the miRNAs on 26 P. Mathijs Voorhoeve et al. BJ cells in the absence or presence of RASV12 (Figure 3B). For this purpose we used a miR-Vec vector that expresses YFP instead of a blasticidin resistance marker and compared the growth rates of YFP-tagged and untagged cells within one population.
2003). , 2004). , 2005). These observations suggest that the suppression of LATS2 explains at least in part the sustained activity of CDK in the presence of high p21cip1 levels in miR-372/3-expressing cells. To investigate the possibility that miR-372 and miR-373 suppress the expression of LATS2, we performed immunoblot analysis of cells expressing wt and mutant miR- 372&3, the cluster and the controls p53kd and empty vector. Both in the absence of RASV12 and in its presence, a significant reduction in LATS2 protein level was observed upon miR-372&3 expression 2.
Advances in Molecular Oncology: Edited under the auspices of the European Institute of Oncology (IEO) and The FIRC Institute of Molecular Oncology Foundation (IFOM) by Maren Oehlmann, Cathal Mahon, Heinz-Peter Nasheuer (auth.), Director Fabrizio d'Adda di Fagagna, Director Susanna Chiocca, Director Fraser McBlane, Director Ugo Cavallaro (eds.)