By Andrej Čretnik (ed.)
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Additional info for Achilles Tendon
Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. The Journal of cell biology, 151(4), 779–788. Fichard A, Kleman, J. , & Ruggiero, F. (1995). Another look at collagen V and XI molecules. Matrix biology : journal of the International Society for Matrix Biology, 14(7), 515–531. Fletcher JR, Esau SP, and MacIntosh BR. (2010) Changes in tendon stiffness and running economy in highly trained distance runners. European Journal of Applied Physiology110: 1037-1046.
The genome wide approach (GWA) tends to use large numbers of cases and controls that are genotyped for many thousands of tagged single nucleotide polymorphisms (SNPs) (Hosking et al, 2011). 0000001 to account for multiple testing (Grant & Hakonarson, 2008). Although GWA studies have clearly advanced our understanding of a number of complex diseases (Grant & Hakonarson, 2008) the technology has not yet been utilised in relation to gene variants that predispose to injuries of the Achilles tendon.
3. Initial investigations In 1989 Jozsa and co-workers conducted a retrospective study on the frequency of different blood groups in a Hungarian population that had suffered from tendon ruptures (Jozsa et al, 1989). They found an abundance (53%) of blood group O in their cohort compared to 31% of the control sample. The abundance of group O was even higher (69%) in individuals who had sustained a re-rupture (Jozsa et al, 1989). Subsequent studies by Kujala and colleagues 28 Achilles Tendon (Kujala et al, 1992) and Kannus and Natri (Kannus & Natri, 1997 as cited by September, 2007) have documented associations between Achilles tendon rupture and blood group distribution.
Achilles Tendon by Andrej Čretnik (ed.)